Integral aircraft passenger seat

Human-engineering approach was used to design integral seat which provides all the safety, comfort, and protective features that can possibly be afforded airline passengers. Results of dynamic impact testing indicated that seat can withstand and attenuate gravity loads of 21-g horizontal and 45-g vertical; by design, seat will withstand lateral g's as well

Easy insert, easy release toggle bolt fastener

Releasable pin-type toggle bolt fastener is constructed so that, when positioned in hole, toggle action prevents its removal and locknut anchors it firmly in place. Fastener is easily removed by loosening locknut and retraction of toggle wings

Fastener apparatus Patent

Releasable, pin-type fastener, easily operated during EV

Databook for human factors engineers. Volume 2 - Common formulas, metrics, definitions

Human factors engineering manual including mathematical formulas, nomographs, conversion tables, units of measurement, and nomenclature

Gastric Metastasis from a Primary Renal Leiomyosarcoma

Primary leiomyosarcoma of the kidney is rare. Here we report a case of metastasis of this tumor to the stomach. A 73-year-old man visited our hospital suffering from general weakness and intermittent tarry stools. He had undergone right nephrectomy for renal leiomyosarcoma 2 years previously. There had been no local recurrence or distant metastasis in the 2-year follow-up period. Endoscopy revealed two submucosal tumors in the stomach. These tumors were diagnosed histologically as leiomyosarcoma and distal gastrectomy was performed. Subsequent histochemical staining confirmed the diagnosis of gastric metastasis from renal leiomyosarcoma. The patient died due to metastases to the liver and bone 9 months after the operation. To the best of our knowledge, this is the first report of gastric metastasis from primary renal leiomyosarcoma

Reevaluation of the 22-1-1 antibody and its putative antigen, EBAG9/RCAS1, as a tumor marker

BACKGROUND: Tumor-associated antigens are appreciated as diagnostic markers, but they have also prompted tremendous efforts to develop tumor-specific immunotherapy. A previously cloned tumor-associated antigen, EBAG9, was initially defined by reactivity with the monoclonal antibody 22-1-1. Functionally, the EBAG9-encoded gene-product was believed to induce apoptosis in activated immune cells. However, using a cell-biological approach we identified EBAG9 as a Golgi-resident modulator of O-linked glycan expression, the latter product was then recognized by the 22-1-1 antibody. Secondly, EBAG9 expression was found physiologically in all murine tissues examined. This raised the question if EBAG9 is tumor-specific and mediates apoptosis itself or through O-linked glycans generated, among them the cognate 22-1-1 antigen Tn. METHODS: We have used immunohistochemistry to detect the expression of 22-1-1 and EBAG9 in various tissues. Correlation between expression of both antigens in cell lines was analysed by immunoblot and flow cytometry. Apoptosis was studied by using flow cytometry and Caspase-Glo™ 3/7 assay kit. Cellular distribution of EBAG9 was analysed by electron and confocal microscopy. RESULTS: Here, we compared expression of the 22-1-1 and EBAG9-defined antigens in normal and neoplastic tissues in situ. In contrast to 22-1-1 staining, EBAG9 is a ubiquitously expressed antigen in all normal and cancerous tissues. Functional studies on the role of 22-1-1 reactive material did not support any evidence for apoptosis induction. Employing electron and confocal microscopy, a refined subcellular localization of EBAG9 at the Golgi was obtained. CONCLUSION: We suggest that the estrogen-inducible EBAG9 gene-product and the 22-1-1 defined antigen are structurally and functionally separate antigens

New Perspectives on Linear Calibration

In univariate calibration, two standard estimators are usually opposed: the classical estimator and the inverse regression estimator. Controversies have followed the use of both estimators and we consider them from a decision-theoretic perspective, establishing the inadmissibility of the classical estimator and the admissibility of the inverse regression estimator. The latter allowing for a Bayesian interpretation, we also develop a fully noninformative study of the calibration model and derive a reference prior which avoids the inconsistency drawbacks of the inverse regression estimator.

Robust estimation of common regression coefficients under spherical symmetry

Elliptically contoured distribution, heteroscedastic linear model, Stein problem, common mean, Graybill-Deal estimator,